Brugia Rapid™ antibody responses in communities of Indonesia in relation to the results of ‘transmission assessment surveys’ (TAS) for the lymphatic filariasis elimination program
Identifieur interne : 002061 ( Main/Exploration ); précédent : 002060; suivant : 002062Brugia Rapid™ antibody responses in communities of Indonesia in relation to the results of ‘transmission assessment surveys’ (TAS) for the lymphatic filariasis elimination program
Auteurs : Rita M. Dewi [Indonésie] ; Sekar Tuti [Indonésie] ; Sitti Ganefa [Indonésie] ; Chairiyah Anwar [Indonésie] ; Ria Larasati [Indonésie] ; Endah Ariyanti [Indonésie] ; Herty Herjati [Indonésie] ; Molly Brady [États-Unis]Source :
- Parasites & Vectors [ 1756-3305 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Brugia (immunologie), Enfant, Enfant d'âge préscolaire, Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (), Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Humains, Indonésie (épidémiologie), Jeune adulte, Mâle, Santé mondiale, Transmission de maladie infectieuse (), Épidémiosurveillance.
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Brugia, Filariose lymphatique.
- sang : Anticorps antihelminthe.
- usage thérapeutique : Filaricides.
- épidémiologie : Filariose lymphatique, Indonésie.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Jeune adulte, Mâle, Santé mondiale, Transmission de maladie infectieuse, Épidémiosurveillance.
- Wicri :
- geographic : Indonésie.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antibodies, Helminth (blood), Brugia (immunology), Child, Child, Preschool, Disease Transmission, Infectious (prevention & control), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (prevention & control), Epidemiological Monitoring, Female, Filaricides (therapeutic use), Global Health, Humans, Indonesia (epidemiology), Male, Middle Aged, Young Adult.
- MESH :
- chemical , blood : Antibodies, Helminth.
- geographic , epidemiology : Indonesia.
- diagnosis : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Brugia, Elephantiasis, Filarial.
- prevention & control : Disease Transmission, Infectious, Elephantiasis, Filarial.
- chemical , therapeutic use : Filaricides.
- Adolescent, Adult, Animals, Child, Child, Preschool, Epidemiological Monitoring, Female, Global Health, Humans, Male, Middle Aged, Young Adult.
Abstract
The Global Programme to Eliminate Lymphatic Filariasis recommends the transmission assessment survey (TAS) as the preferred methodology for determining whether mass drug administration can be stopped in an endemic area. Because of the limited experience available globally with the use of Brugia Rapid™ tests in conducting TAS in
The study analyzes the Brugia Rapid™ antibody responses and microfilaremia in all ages at three study sites in: i) a district which was classified as non-endemic, ii) a district which passed TAS, and iii) a district which failed TAS. Convenience sampling was done in each site, in one to three purposefully selected villages with a goal of 500 samples in each district.
A total of 1543 samples were collected from residents in all three study sites. In the site which was classified as non-endemic and where MDA had not been conducted, 5 % of study participants were antibody positive, none was positive for microfilaremia, and age-specific antibody prevalence peaked at almost 8 % in the 25–34 year-old age range, with no antibody-positive results found in children under eight years of age. In the site that had passed TAS, 1 % of participants were antibody positive and none was positive for microfilaremia. In the site which failed TAS, 15 % of participants were antibody positive, 0.2 % were microfilaremic, and age-specific antibody prevalence was highest in 6–7 year olds (30 %), but above 8 % in all age levels above 8 years old.
These results from districts which followed the current WHO guidance for mapping, MDA, and implementing TAS, while providing antibody profiles of treated and untreated populations under programmatic settings, support the choice of antibody prevalence in the 6- and 7-year-old age group in TAS for making stopping MDA decisions. Since only one study participant was microfilaremic, no conclusions could be drawn about the relationship between antibodies and microfilaremia and further longitudinal studies are required to understand this relationship.
Url:
DOI: 10.1186/s13071-015-1093-x
PubMed: 26427536
PubMed Central: 4589901
Affiliations:
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Dewi</name><affiliation wicri:level="1"><nlm:aff id="Aff1">National Institute of Health Research and Development, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta, 10560 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>National Institute of Health Research and Development, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Tuti, Sekar" sort="Tuti, Sekar" uniqKey="Tuti S" first="Sekar" last="Tuti">Sekar Tuti</name><affiliation wicri:level="1"><nlm:aff id="Aff1">National Institute of Health Research and Development, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta, 10560 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>National Institute of Health Research and Development, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Ganefa, Sitti" sort="Ganefa, Sitti" uniqKey="Ganefa S" first="Sitti" last="Ganefa">Sitti Ganefa</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Sub-Directorate of Filariasis & Helminthiasis Control, Directorate of Vector Borne Disease Control, Directorate General of Communicable Disease and Environmental Health, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta, 10560 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>Sub-Directorate of Filariasis & Helminthiasis Control, Directorate of Vector Borne Disease Control, Directorate General of Communicable Disease and Environmental Health, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Anwar, Chairiyah" sort="Anwar, Chairiyah" uniqKey="Anwar C" first="Chairiyah" last="Anwar">Chairiyah Anwar</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Sub-Directorate of Filariasis & Helminthiasis Control, Directorate of Vector Borne Disease Control, Directorate General of Communicable Disease and Environmental Health, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta, 10560 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>Sub-Directorate of Filariasis & Helminthiasis Control, Directorate of Vector Borne Disease Control, Directorate General of Communicable Disease and Environmental Health, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Larasati, Ria" sort="Larasati, Ria" uniqKey="Larasati R" first="Ria" last="Larasati">Ria Larasati</name><affiliation wicri:level="1"><nlm:aff id="Aff3">RTI International-Indonesia, Menara Thamrin, 15th Floor, Suite 1503, Jl. M.H. Thamrin Kav. 3, Jakarta, 10250 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>RTI International-Indonesia, Menara Thamrin, 15th Floor, Suite 1503, Jl. M.H. Thamrin Kav. 3, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Ariyanti, Endah" sort="Ariyanti, Endah" uniqKey="Ariyanti E" first="Endah" last="Ariyanti">Endah Ariyanti</name><affiliation wicri:level="1"><nlm:aff id="Aff1">National Institute of Health Research and Development, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta, 10560 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>National Institute of Health Research and Development, Indonesia Ministry of Health, Jl. Percetakan Negara No. 29, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Herjati, Herty" sort="Herjati, Herty" uniqKey="Herjati H" first="Herty" last="Herjati">Herty Herjati</name><affiliation wicri:level="1"><nlm:aff id="Aff3">RTI International-Indonesia, Menara Thamrin, 15th Floor, Suite 1503, Jl. M.H. Thamrin Kav. 3, Jakarta, 10250 Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>RTI International-Indonesia, Menara Thamrin, 15th Floor, Suite 1503, Jl. M.H. Thamrin Kav. 3, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Brady, Molly" sort="Brady, Molly" uniqKey="Brady M" first="Molly" last="Brady">Molly Brady</name><affiliation wicri:level="2"><nlm:aff id="Aff4">RTI International, 701 13th Street NW, Suite 750, Washington, DC 20008 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>RTI International, 701 13th Street NW, Suite 750, Washington</wicri:cityArea></affiliation></author></analytic><series><title level="j">Parasites & Vectors</title><idno type="eISSN">1756-3305</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Brugia (immunology)</term><term>Child</term><term>Child, Preschool</term><term>Disease Transmission, Infectious (prevention & control)</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Epidemiological Monitoring</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Global Health</term><term>Humans</term><term>Indonesia (epidemiology)</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Brugia (immunologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Indonésie (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Santé mondiale</term><term>Transmission de maladie infectieuse ()</term><term>Épidémiosurveillance</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Indonesia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Transmission, Infectious</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Indonésie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Epidemiological Monitoring</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filariose lymphatique</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Santé mondiale</term><term>Transmission de maladie infectieuse</term><term>Épidémiosurveillance</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Indonésie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The Global Programme to Eliminate Lymphatic Filariasis recommends the transmission assessment survey (TAS) as the preferred methodology for determining whether mass drug administration can be stopped in an endemic area. Because of the limited experience available globally with the use of Brugia Rapid™ tests in conducting TAS in <italic>Brugia spp.</italic> areas, we explored the relationship between the antibody test results and <italic>Brugia spp.</italic> infection as detected by microfilaremia in different epidemiological settings.</p></sec><sec><title>Methods</title><p>The study analyzes the Brugia Rapid™ antibody responses and microfilaremia in all ages at three study sites in: i) a district which was classified as non-endemic, ii) a district which passed TAS, and iii) a district which failed TAS. Convenience sampling was done in each site, in one to three purposefully selected villages with a goal of 500 samples in each district.</p></sec><sec><title>Results</title><p>A total of 1543 samples were collected from residents in all three study sites. In the site which was classified as non-endemic and where MDA had not been conducted, 5 % of study participants were antibody positive, none was positive for microfilaremia, and age-specific antibody prevalence peaked at almost 8 % in the 25–34 year-old age range, with no antibody-positive results found in children under eight years of age. In the site that had passed TAS, 1 % of participants were antibody positive and none was positive for microfilaremia. In the site which failed TAS, 15 % of participants were antibody positive, 0.2 % were microfilaremic, and age-specific antibody prevalence was highest in 6–7 year olds (30 %), but above 8 % in all age levels above 8 years old.</p></sec><sec><title>Conclusions</title><p>These results from districts which followed the current WHO guidance for mapping, MDA, and implementing TAS, while providing antibody profiles of treated and untreated populations under programmatic settings, support the choice of antibody prevalence in the 6- and 7-year-old age group in TAS for making stopping MDA decisions. Since only one study participant was microfilaremic, no conclusions could be drawn about the relationship between antibodies and microfilaremia and further longitudinal studies are required to understand this relationship.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Bk" uniqKey="Chu B">BK Chu</name></author><author><name sortKey="Deming, M" uniqKey="Deming M">M Deming</name></author><author><name sortKey="Biritwum, N K" uniqKey="Biritwum N">N-K Biritwum</name></author><author><name sortKey="Bougma, Wr" uniqKey="Bougma W">WR Bougma</name></author><author><name sortKey="Dorkenoo, Am" uniqKey="Dorkenoo A">AM Dorkenoo</name></author><author><name sortKey="El Setouhy, M" uniqKey="El Setouhy M">M El-Setouhy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gass, K" uniqKey="Gass K">K Gass</name></author><author><name sortKey="De Rochars Mve, B" uniqKey="De Rochars Mve B">B de Rochars MVE</name></author><author><name sortKey="Boakye, D" uniqKey="Boakye D">D Boakye</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Fischer, Pu" uniqKey="Fischer P">PU Fischer</name></author><author><name sortKey="Gyapong, J" uniqKey="Gyapong J">J Gyapong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahmah, N" uniqKey="Rahmah N">N Rahmah</name></author><author><name sortKey="Shenoy, Rk" uniqKey="Shenoy R">RK Shenoy</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author><author><name sortKey="Weiss, N" uniqKey="Weiss N">N Weiss</name></author><author><name sortKey="Gilmour, K" uniqKey="Gilmour K">K Gilmour</name></author><author><name sortKey="Maizels, Rm" uniqKey="Maizels R">RM Maizels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noordin, R" uniqKey="Noordin R">R Noordin</name></author><author><name sortKey="Muhi, J" uniqKey="Muhi J">J Muhi</name></author><author><name sortKey="Md Idris, Z" uniqKey="Md Idris Z">Z Md Idris</name></author><author><name sortKey="Arifin, N" uniqKey="Arifin N">N Arifin</name></author><author><name sortKey="Kiyu, A" uniqKey="Kiyu A">A Kiyu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lammie, Pj" uniqKey="Lammie P">PJ Lammie</name></author><author><name sortKey="Weil, G" uniqKey="Weil G">G Weil</name></author><author><name sortKey="Noordin, R" uniqKey="Noordin R">R Noordin</name></author><author><name sortKey="Kaliraj, P" uniqKey="Kaliraj P">P Kaliraj</name></author><author><name sortKey="Steel, C" uniqKey="Steel C">C Steel</name></author><author><name sortKey="Goodman, D" uniqKey="Goodman D">D Goodman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weil, Gj" uniqKey="Weil G">GJ Weil</name></author><author><name sortKey="Ramzy, Rmr" uniqKey="Ramzy R">RMR Ramzy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamlin, Kl" uniqKey="Hamlin K">KL Hamlin</name></author><author><name sortKey="Moss, Dm" uniqKey="Moss D">DM Moss</name></author><author><name sortKey="Priest, Jw" uniqKey="Priest J">JW Priest</name></author><author><name sortKey="Roberts, J" uniqKey="Roberts J">J Roberts</name></author><author><name sortKey="Kubofcik, J" uniqKey="Kubofcik J">J Kubofcik</name></author><author><name sortKey="Gass, K" uniqKey="Gass K">K Gass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steel, C" uniqKey="Steel C">C Steel</name></author><author><name sortKey="Kubofcik, J" uniqKey="Kubofcik J">J Kubofcik</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weil, Gj" uniqKey="Weil G">GJ Weil</name></author><author><name sortKey="Kastens, W" uniqKey="Kastens W">W Kastens</name></author><author><name sortKey="Susapu, M" uniqKey="Susapu M">M Susapu</name></author><author><name sortKey="Laney, Sj" uniqKey="Laney S">SJ Laney</name></author><author><name sortKey="Williams, Sa" uniqKey="Williams S">SA Williams</name></author><author><name sortKey="King, Cl" uniqKey="King C">CL King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Supali, T" uniqKey="Supali T">T Supali</name></author><author><name sortKey="Rahmah, N" uniqKey="Rahmah N">N Rahmah</name></author><author><name sortKey="Djuardi, Y" uniqKey="Djuardi Y">Y Djuardi</name></author><author><name sortKey="Sartono, E" uniqKey="Sartono E">E Sartono</name></author><author><name sortKey="Ruckert, P" uniqKey="Ruckert P">P Rückert</name></author><author><name sortKey="Fischer, P" uniqKey="Fischer P">P Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jamail, M" uniqKey="Jamail M">M Jamail</name></author><author><name sortKey="Andrew, K" uniqKey="Andrew K">K Andrew</name></author><author><name sortKey="Junaidi, D" uniqKey="Junaidi D">D Junaidi</name></author><author><name sortKey="Krishnan, Ak" uniqKey="Krishnan A">AK Krishnan</name></author><author><name sortKey="Faizal, M" uniqKey="Faizal M">M Faizal</name></author><author><name sortKey="Rahmah, N" uniqKey="Rahmah N">N Rahmah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Supali, T" uniqKey="Supali T">T Supali</name></author><author><name sortKey="Djuardi, Y" uniqKey="Djuardi Y">Y Djuardi</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Noordin, R" uniqKey="Noordin R">R Noordin</name></author><author><name sortKey="Ruckert, P" uniqKey="Ruckert P">P Rückert</name></author><author><name sortKey="Fischer, Pu" uniqKey="Fischer P">PU Fischer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Indonésie</li><li>États-Unis</li></country><region><li>District de Columbia</li></region></list><tree><country name="Indonésie"><noRegion><name sortKey="Dewi, Rita M" sort="Dewi, Rita M" uniqKey="Dewi R" first="Rita M." last="Dewi">Rita M. Dewi</name></noRegion><name sortKey="Anwar, Chairiyah" sort="Anwar, Chairiyah" uniqKey="Anwar C" first="Chairiyah" last="Anwar">Chairiyah Anwar</name><name sortKey="Ariyanti, Endah" sort="Ariyanti, Endah" uniqKey="Ariyanti E" first="Endah" last="Ariyanti">Endah Ariyanti</name><name sortKey="Ganefa, Sitti" sort="Ganefa, Sitti" uniqKey="Ganefa S" first="Sitti" last="Ganefa">Sitti Ganefa</name><name sortKey="Herjati, Herty" sort="Herjati, Herty" uniqKey="Herjati H" first="Herty" last="Herjati">Herty Herjati</name><name sortKey="Larasati, Ria" sort="Larasati, Ria" uniqKey="Larasati R" first="Ria" last="Larasati">Ria Larasati</name><name sortKey="Tuti, Sekar" sort="Tuti, Sekar" uniqKey="Tuti S" first="Sekar" last="Tuti">Sekar Tuti</name></country><country name="États-Unis"><region name="District de Columbia"><name sortKey="Brady, Molly" sort="Brady, Molly" uniqKey="Brady M" first="Molly" last="Brady">Molly Brady</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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